Isolation of Three Novel Human Genes Encoding G Protein-Coupled Receptors
作者:
MICHAEL HEIBER,
JOHN M. DOCHERTY,
GIRISH SHAH,
TUAN NGUYEN,
REGINA CHENG,
HENRY H.Q. HENG,
ADRIANO MARCHESE,
LAP-CHEE TSUI,
XIAOMEI SHI,
SUSAN R. GEORGE,
BRIAN F. O'DOWD,
期刊:
DNA and Cell Biology
(MAL Available online 1995)
卷期:
Volume 14,
issue 1
页码: 25-35
ISSN:1044-5498
年代: 1995
DOI:10.1089/dna.1995.14.25
数据来源: MAL
摘要:
ABSTRACTWe have cloned and mapped the chromosomal location of three novel human genes encoding G protein-coupled receptors that we have named GPR6, GPR5, and GPR4. The entire coding region for each of these genes was contained on single exons. Gene GPR6 encoded a receptor that shared closest identity (71% in the transmembrane regions) with the human orphan receptor GPR3 and was localized to chromosome 6 (q21–q22.1). Northern blot analysis revealed that GPR6 transcripts were abundant in the human putamen and to a lesser extent in the frontal cortex, hippocampus, and hypothalamus. Gene GPR5 encoded a receptor that most closely resembled the orphan receptor RBS11 (48% in the transmembrane regions) and the MIP 1α/RANTES receptor (45% in the transmembrane regions) and was localized to chromosome 3 (p21.3–p21.1). Gene GPR4 shared identity (40% in the transmembrane regions) with the human platelet-activating factor receptor and was localized to chromosome 19 (q13.2–
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