Regeneration and the immune system I.In vitroandin vivoactivation of lymphocytes by liver regeneration and the role of Kupffer cells in stimulation
作者:
Seiko Miyahara,
Kozo Yokomuro,
Hidemi Takahashi,
Yoshitami Kimura,
期刊:
European Journal of Immunology
(WILEY Available online 1983)
卷期:
Volume 13,
issue 11
页码: 878-883
ISSN:0014-2980
年代: 1983
DOI:10.1002/eji.1830131104
出版商: WILEY‐VCH Verlag GmbH
数据来源: WILEY
摘要:
AbstractWhen syngeneic lymphocytes and mitomycin C‐treated regenerating liver cells, prepared from partially hepatectomized mice, are cultured together, thein vitroDNA synthesis is activated (sMLHLR: syngeneic mixed hepatectomized‐liver cell‐lymphocyte culture). The Ia+Kupffer cells play an important role as stimulators in the response, since the stimulating activity of regenerating liver cells is lost either by the pretreatment with anti‐Ia monoclonal antibody plus complement or by the removing Kupffer cells from them. The lymphocytes are also activatedin vivoduring liver regeneration following partial hepatectomy. When lymphocytes, prepared from hepatectomized mice, are cultured with regenerating liver cells, the lymphocytes are stimulated to accelerate their DNA synthesis in a manner typical of the secondary immune responses (secondary sMLHLR). In primary sMLHLR, the responder cells are mainly Lyt‐1+, whereas, in secondary sMLHLR, they are mainly Lyt‐2+. The mechanism of changing the Lyt phenotype of major responder cells from Lyt‐1 to Lyt‐2 during sMLH
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