Ovarian Oxytocin and Neurophysin Concentrations in the Cynomolgus Monkey (Macaca Fascicularis)
作者:
AmicoJanet A.,
ZeleznikAnthony J.,
期刊:
Endocrine Research
(Taylor Available online 1990)
卷期:
Volume 16,
issue 1
页码: 17-30
ISSN:0743-5800
年代: 1990
DOI:10.1080/07435809009035918
出版商: Taylor&Francis
数据来源: Taylor
摘要:
The neurohypophysial hormone oxytocin has previously been found in the ovaries of several animal species. In ruminants ovarian oxytocin is postulated to have a luteolytic function, because of its high concentrations in the corpus luteum. In primates the role of ovarian oxytocin is not known. In the present study we measured the immunoreactive oxytocin and oxytocin-neurophysin content in paired ovaries removed from cynomolgus monkeys (Macaca fascicularis) during the late luteal phase of the cycle (Days 12-14 heluteal phase or Days 26-28 of a menstrual cycle). Each animal was pulsed with synthetic gonadotropin-releasing hormone to maintain normal menstrual cyclicity. The concentration of oxytocin and its neurophysin during the late luteal phase was greater in the non-corpus luteum than corpus luteum-bearing ovary. By high pressure liquid chromatography and bioassay the oxytocin in both the corpus luteal and non-corpus luted ovaries was similar to synthetic and posterior pituitary oxytocin. The finding of high concentrations of immunoreactive oxytocin in the non-corpus luteum-bearing ovary suggests that the function of ovarian oxytocin in primates may not be confined specifically to the corpus luteum.
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