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Biomarkers for the Detection of Bladder Cancer

 

作者: Jeffrey Ross,   Michael Cohen,  

 

期刊: Advances in Anatomic Pathology  (OVID Available online 2001)
卷期: Volume 8, issue 1  

页码: 37-45

 

ISSN:1072-4109

 

年代: 2001

 

出版商: OVID

 

关键词: Bladder cancer;Biomarkers;Prognostic factors

 

数据来源: OVID

 

摘要:

In this subject review, a series of morphology-based and molecular markers were compared with urinary cytology for the detection of recurrent urothelial neoplasia. Among the various biomarkers reviewed, the average published sensitivity and specificity for the Bard BTA test was 60% and 77%; the NMP22 Test was 67% and 72%; the telomerase assay was 77% and 85%; and the microsatellite assay was 89% and 100%. DNA ploidy measurements and immunoassays designed to detect keratins, proteins, hyaluronidase, growth factors, cell adhesion molecules, fibrinogen degradation products, cell cycle regulators, and molecular markers were also included. Although the performance features of these biomarkers have varied and the cytologic methods to which they have been compared have not been standardized, several of the procedures have received considerable support from urologists as assisting them in the management of their patients.

 

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