Anesthetic Pregnanes Counteract Androgen-Induced Defeminization
作者:
G. Gonzalez-Mariscal,
A. Fernandez-Guasti,
C. Beyer,
期刊:
Neuroendocrinology
(Karger Available online 1982)
卷期:
Volume 34,
issue 5
页码: 357-362
ISSN:0028-3835
年代: 1982
DOI:10.1159/000123328
出版商: S. Karger AG
关键词: Hypothalamic virilization;Neonatal androgenization;Neonatal rats;Brain development;5β-Pregnanes;Anesthetic pregnanes;Prevention of defeminization
数据来源: Karger
摘要:
The capacity of various pregnanes for counteracting androgen-induced defeminization was evaluated in an attempt to define some cellular mechanisms involved in the defeminization process. 5-day-old female rats received 60 µg testosterone propionate (TP) along with one of various pregnanes:progesterone, 5β-pregnandione, 5β,3α-pregnanolone, 5β,3β-pregnanolone, 5α-pregnandione, 5α,3β-pregnanolone, 5α,3α-pregnanolone or chlormadinone acetate. Protection against defeminization was defined as a significantly smaller proportion of anovulatory animals in a group compared to the control TP group. Data were analyzed at 60, 90 and 120 days of age. The anesthetic potency of the pregnanes was evaluated in 5-day-old male rats through the analysis of EEG and EMG records. Anesthetic pregnanes – progesterone, 5β-pregnandione and 5β,3α-pregnanolone – counteracted defeminization while nonanesthetic pregnanes – 5α-pregnanes, chlormadinone acetate and 5β,3β-pregnanolone – did not. The results show a clear relation between anesthetic capacity and protectio
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