Death as a result of anaphylaxis remains rare and is only occasionally related to ingestion of common substances. This article reports a death due to an allergic reaction to ethanol, as well as a review of the reported deaths in the literature attributed to ethanol. This report emphasizes the importance of awareness of such obscure allergies by forensic pathologists, the significance of antemortem testing, and the value of gathering accurate medical information, both antemortem and postmortem.