Effects of Thiopental, Pentobarbital, and Ketamine on Endothelin-Induced Constriction of Porcine Cerebral Arteries
作者:
Kiichiro Taga,
Satoru Fukuda,
Nobuhiro Nishimura,
Atsushi Tsukui,
Mutsumi Morioka,
Koki Shimoji,
期刊:
Anesthesiology
(OVID Available online 1990)
卷期:
Volume 72,
issue 5
页码: 939-941
ISSN:0003-3022
年代: 1990
出版商: OVID
关键词: Anesthetics: intravenous;ketamine;pentobarbital;thiopental;Artery: cerebral;Pharmacology, calcium channel blocking drug: diltiazem;Species: swine;Vasoconstriction: endothelin
数据来源: OVID
摘要:
Contractile mechanisms of endothelin, a newly isolated vasoactive substance from endothelium, were evaluated in anterior cerebral arteries (ACA). Furthermore, the effects of thiopental, pentobarbital, ketamine, and diltiazem on the endothelin-induced cerebral vasoconstriction were also studied. Endothelin induced cerebral arterial contractions in concentrations above 3 × 10−10M. The median effective concentration (ED50: ×10−9M) of endothelin was 2.1 ± 0.7 (n = 6). Endothelin did not elicit contractions in preparations soaked in Ca2+-free solution, but addition of 2.5 mM Ca2+to the baths induced marked contractions. Thiopental and pentobarbital attenuated endothelin-induced contractions at concentrations above 3 × 10−4M, while ketamine was effective above10−3M. In contrast, diltiazem decreased endothelin-induced vasoconstriction at 10−6M. The findings suggest that endothelin may cause contractions of porcine cerebral arteries by influx of Ca2+through Ca2+channels. The cerebral vasomotion induced by endothelin, however, does not seem to be influenced by clinical doses of barbiturates and ketamine.
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