Toward Personalized Immunotherapy for Non-Hodgkin LymphomaTargeting the Idiotypic Immunoglobulin
作者:
Anne C Armstrong,
Eleanor J Cheadle,
Robert E Hawkins,
期刊:
BioDrugs
(ADIS Available online 2005)
卷期:
Volume 19,
issue 5
页码: 289-297
ISSN:1173-8804
年代: 2005
出版商: ADIS
关键词: Anticancer vaccines, general;Non Hodgkin's lymphoma, general
数据来源: ADIS
摘要:
The idiotypic determinants of B-cell lymphomas, formed by cell-specific rearrangement of the immunoglobulin genes, are unique and are therefore a suitable target against which to direct immunotherapy. Recent advances in our understanding of the fundamental mechanisms behind an effective immune response, coupled with advances in genetic engineering techniques, have led to a renewed interest in immunotherapy. Early clinical studies have confirmed the immunogenicity of the idiotypic antigen in patients with lymphoma. This review discusses the different methods of idiotypic vaccination currently under investigation in the clinic, including protein, genetic, and cellular vaccines. Protein vaccines are the most clinically advanced, with phase III trials of idiotypic protein linked to GM-CSF currently underway. DNA vaccines are easier to produce but to date only appear to be weakly immunogenic in man. Dendritic cell vaccines have shown promise but their use may be limited by the complexity of this approach. This review also highlights other approaches not yet in the clinic but that have shown promise in the laboratory, such as viral vaccines and T-cell therapy.
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