SummaryHyperœstrogenism is generally recognised as the cause of metropathia hæmorrhagia associated with hyperplastic endometrium, a syndrom described many years ago by Schröder.However hyperœstrogenism does not always produce such well characterized symptoms. In some cases hyperœstrogenism remains in discussion when endometrial biopsy shows for instance a picture not corresponding to the period of the menstrual cycle at which the biopsy was taken. Il is the author’s opinion that such cases are frequently observed in a clinical characteristic type of women.In such type of hyperœstrogenism, complains are not limited to the genital sphere. General symptoms are met with : a slight enlargement of the thyroid gland is frequently noted with symptoms suggesting moderate Basedow disease ; congestive manifestations in the mammary glands with microkystic mastitis are observed as well as a tendency to hyperadrenalism with slight hirsutism.Such clinical signs suggest hyperactivity of several glands rather than pure hyperœstrogenism, perhaps also hyperpituitarism.