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The effect of methyl linoleate hydroperoxide (MLHP), a possible toxic intermediate of ozone, on human normal and glucose‐6‐phosphate dehydrogenase (G‐6‐PD) deficient erythrocytes

 

作者: PerryS. Williams,   EdwardJ. Calabrese,   GaryS. Moore,  

 

期刊: Journal of Environmental Science and Health . Part A: Environmental Science and Engineering  （Taylor Available online 1983）
卷期: Volume 18, issue 1  

页码: 37-49

 

ISSN:0360-1226

 

年代: 1983

 

DOI:10.1080/10934528309375091

 

出版商: Taylor & Francis Group

 

关键词: Ozone;Glucose‐6‐Phosphate Dehydrogenase deficiency

 

数据来源: Taylor

 

摘要:

Erythrocytes of both normal and G‐6‐PD deficient humans responded in a dose‐dependent manner to the oxidant stress of MLHP as measured by decreases in G‐6‐PD activity, increases in methemoglobin (METHB) levels and decreases in reduced glutathione (GSH). The G‐6‐PD deficient eryth‐rocytes displayed a markedly enhanced sensitivity to MLPH induced decreases in G‐6‐PD activity and METHB increases while being less sensitive than normalerythrocytes to changes in GSH levels.

 

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