Linkage Disequilibrium and Linkage Information from One-Child Families
作者:
J.J Tai,
W.H. Song,
期刊:
Human Heredity
(Karger Available online 1991)
卷期:
Volume 41,
issue 5
页码: 316-323
ISSN:0001-5652
年代: 1991
DOI:10.1159/000154019
出版商: S. Karger AG
关键词: Lod score;Phase proportion;Transition matrix
数据来源: Karger
摘要:
In linkage analysis a single-child family is usually considered to be completely uninformative. This article shows that such a family can provide information on linkage disequilibrium, even if it provides no information on linkage equilibrium. A transition matrix consisting of the recombination fraction and the phase proportion is proposed to study the genetic transmission from a pair of parents to their single child. The information about linkage for a single-child family is shown to be confounded by the phase proportion. This explains why such a family used to be considered uninformative under the assumption of linkage equilibrium. By reparametrizing the recombination fraction and the phase proportion into one parameter, it is demonstrated that extracting information on linkage disequilibrium is feasible. The study of power of the testing method proposed here is carried out by simulation.
点击下载:
PDF
(921KB)
返 回