Two Possible Mechanisms for Precocious Puberty Induced in Female Rats by Pituitary Grafts
作者:
Dolores Gonzalez,
Francisco López,
José E. Sanchez Criado,
Enrique Aguilar,
期刊:
Neuroendocrinology
(Karger Available online 1986)
卷期:
Volume 42,
issue 4
页码: 323-327
ISSN:0028-3835
年代: 1986
DOI:10.1159/000124458
出版商: S. Karger AG
关键词: Puberty;Prolactin;Pituitary grafts
数据来源: Karger
摘要:
Many reports indicate that prolactin has a role in puberty occurrence. The present study was developed to evaluate the action of pituitary grafts on puberty. Female rats grafted on day 21 with ‘adult’ (90 days old) or ‘young’ (21 days old) pituitaries showed precocious vaginal opening and first estrus. The puberty advancement induced by ‘adult’ transplants was due to an increase in plasma prolactin values and can be blocked by bromocriptine treatment. The puberty advancement induced by ‘young’ transplants was not associated with increased prolactin levels and cannot be blocked by bromocriptine. These results suggest the existence of two possible mechanisms in precocious puberty induced by pituitary grafts: a prolactin-dependent one and another one not directly related
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