The Role of Alpha-2-Adrenoceptors in the Control of ACTH Secretion; Interaction with the Opioid System
作者:
Saad Al-Damluji,
Pierre Bouloux,
Anne White,
Michael Besser,
期刊:
Neuroendocrinology
(Karger Available online 1990)
卷期:
Volume 51,
issue 1
页码: 76-81
ISSN:0028-3835
年代: 1990
DOI:10.1159/000125319
出版商: S. Karger AG
关键词: ACTH;Corticotrophin;Catecholamines;Adrenoceptors;Opioids
数据来源: Karger
摘要:
This study examined the effects of an alpha-2-adrenoceptor antagonist on the secretion of ACTH basally and in response to the opioid antagonist naloxone, which is known to stimulate ACTH secretion by an adrenergic mechanism. Eight normal men were given, in double-blind, random order, intravenous infusions of normal saline (placebo), idazoxan (alpha-2-adrenoceptor antagonist), naloxone and the combination of idazoxan and naloxone. Naloxone increased plasma ACTH and cortisol concentrations in comparison to placebo. Idazoxan significantly enhanced the ACTH and cortisol responses to naloxone but had no effect on plasma ACTH or cortisol concentrations when given alone. These findings suggest that during some conditions of increased ACTH secretion, inhibitory alpha-2-adrenoceptors are activated and that these receptors limit the ACTH response. This provides an explanation for some of the apparent contradictions in interpreting the data from previous studies on the effects of catecholamines on the secretion of ACTH.
点击下载:
PDF
(1190KB)
返 回