Renal Transplantation in Systemic Lupus erythematosus: One Center’s Experience
作者:
David Roth,
Martin Milgrom,
Violet Esquenazi,
Jose Strauss,
Gaston Zilleruelo,
Joshua Miller,
期刊:
American Journal of Nephrology
(Karger Available online 1987)
卷期:
Volume 7,
issue 5
页码: 367-374
ISSN:0250-8095
年代: 1987
DOI:10.1159/000167615
出版商: S. Karger AG
关键词: Renal transplantation;Systemic lupus erythematosus;Recurrent disease;End-stage renal disease
数据来源: Karger
摘要:
A retrospective analysis of 15 renal transplant patients with end-stage renal disease (ESRD) secondary to systemic lupus erythematosus (SLE) was performed. Overall actuarial patient and graft survival at 6 years was 93 and 84%, respectively. Recipients of HLA-identical kidneys did not appear to be at increased risk of allograft failure due to rejection or recurrent disease. Two biopsy-proven cases of recurrent lupus involving the allograft were observed and are discussed. Those patients currently experiencing excellent graft function (creatinine < 2 mg/dl) had a significantly longer pretransplantation dialytic interval than the group whose most recent serum creatinine exceeds 2 mg/dl (or returned to dialysis). Posttransplantation monitoring of antinuclear antibody, antidouble-stranded DNA, C3, C4, and circulating immune complexes was not predictive of renal or extrarenal disease activity. Renal transplantation should be considered an excellent therapeutic modality for the lupus patient with ESRD, although an interim period on dialysis of at least 1 year seems warranted.
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