Targeting Drugs to the Colon: Delivery Systems for Oral Administration
作者:
AshfordM.,
FellJ.,
期刊:
Journal of Drug Targeting
(Taylor Available online 1994)
卷期:
Volume 2,
issue 3
页码: 241-257
ISSN:1061-186X
年代: 1994
DOI:10.3109/10611869408996806
出版商: Taylor&Francis
关键词: Colonic delivery;pH;timed release;microbial degradation
数据来源: Taylor
摘要:
AbstractThe oral delivery of drugs to the colon has applications in a variety of therapeutic areas. This review is concerned with the approaches taken to achieve a universal system for delivery. The design of such a system requires the identification and exploitation of a unique feature of the colonic environment. The use of transit times, pH and bacterial enzymes are critically assessed. In addition, the system must provide protection for the drug during transit to the colon. Upper gastro-intestinal physiology and the transit of pharmaceuticals through these regions are reviewed with reference to their relevance in achieving site specificity.
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