Chromosome breaks and sister chromatid exchanges in albinos in Nigeria
作者:
Jaroslav Cervenka,
Carl J. Witkop,
Anezi N. Okoro,
Richard A. King,
期刊:
Clinical Genetics
(WILEY Available online 1979)
卷期:
Volume 15,
issue 1
页码: 17-21
ISSN:0009-9163
年代: 1979
DOI:10.1111/j.1399-0004.1979.tb02024.x
出版商: Blackwell Publishing Ltd
关键词: Albinism;chromosomal breaks;mutation;sister chromosome exchanges;skin cancer.
数据来源: WILEY
摘要:
The prevalence of squamous cell carcinoma of the skin in albinos reaches approximately 90 % in patients over 20 years of age in the vicinity of Enugu, Nigeria. Chromosome breaks and sister chromatid exchanges (SCE) were evaluated in tyrosinase‐positive oculocutaneous albinos and pigmented controls of Ibo extraction who were life‐long residents of Nigeria. No difference in the frequency of chromosomal breaks in 14 albinos compared to 6 pigmented controls, and no differences in the frequency of SCE in 9 albinos compared to 3 controls could be detected. Increased chromosomal abnormalities in lymphocytes do not appear to be associated with albinism or fulminating skin cancer present in albinos in the trop
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