AbstractIndole‐3‐carboxylic acid hydrazide3was prepared and was treated with aromatic aldehydes in ethanol to give the corresponding hydrazone derivatives4–7in good yields. The indole carbohydrazide was incorporated into the 3‐indolyloxadiazoles8–11and18, 3‐indolyltriazoles13–17and35, 3‐indolylpyrazole derivatives19–23and carbamate derivatives26–27. Furthermore, interaction of the carboazide24with hydrazine hydrate in refluxing toluene afforded the corresponding semicarbazide derivative30. The thiadiazine derivative34was also prepared. Some of these compounds were screenedin vitrofor their antibacterial and