Diabetic Nephropathy: New Directions in Management
作者:
SirmonwMaryella D.,
KirkpatrickWanda G.,
期刊:
Renal Failure
(Taylor Available online 1991)
卷期:
Volume 13,
issue 2-3
页码: 51-59
ISSN:0886-022X
年代: 1991
DOI:10.3109/08860229109022148
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Approximately 6 million people in the United States are known to be diabetic, with an estimated 4 million individuals having undiagnosed diabetes mellitus. The metabolic derangements of both insulin-dependent diabetes mellitus (IDDM) and noninsulin-dependent diabetes mellitus (NIDDM) result in widespread end-organ damage, including progressive kidney failure. Since its initial description in 1936, the incidence of diabetic nephropathy has progressively increased, and it is now the most common cause of newly diagnosed end-stage renal disease (ESRD) requiring renal replacement therapy in the United States. While basic research efforts into pathogenesis continue, there is significant interest in clinical interventions that may slow the progression of diabetic renal disease. In addition, the options available for renal replacement therapy have increased and improved substantially in recent years.
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