Carbon monoxide regulates cerebral blood flow in epileptic seizures but not in hypercapnia
作者:
Céline Montécot,
Jacques Seylaz,
Elisabeth Pinard,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 10
页码: 2341-2346
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Cerebral blood flow;Carbon monoxide;Epilepsy;Hypercapnia;Kainate
数据来源: OVID
摘要:
CARBON monoxide (CO) is an endogenously produced gas sharing many properties with nitric oxide (NO), notably activating soluble guanylate cyclase and relaxing blood vessels. The brain can generate high quantities of CO from a constitutive enzyme, haem oxygenase (HO-2). To determine whether CO is involved in the regulatory mechanisms of cerebral blood flow (CBF), two conditions associated with a reproducible CBF increase were studied in rats: epileptic seizures induced by kainate, and hypercapnia. The HO inhibitor tin protoporphyrin (Sn-PP) did not modify the basal level of CBF, significantly reduced the increase in CBF during status epilepticus, and did not affect the cerebrovascular response to hypercapnia. It is concluded that CO participates in the regulation of CBF in specific conditions, notably those associated with glutamate release.
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