首页   按字顺浏览 期刊浏览 卷期浏览 Effects of 17β-Estradiol, Progesterone and Tamoxifen on in vitro Proliferation of Human...
Effects of 17β-Estradiol, Progesterone and Tamoxifen on in vitro Proliferation of Human Pituitary Adenomas: Correlation with Specific Cellular Receptors

 

作者: Brunella Caronti,   Guido Palladini,   Maria Gabriella Bevilacqua,   Elisa Petrangeli,   Bernardo Fraioli,   Giampaolo Cantore,   Guido Tamburrano,   Carmine Maria Carapella,   Marie Lise Jaffrain-Rea,  

 

期刊: Tumor Biology  （Karger Available online 1993）
卷期: Volume 14, issue 1  

页码: 59-68

 

ISSN:1010-4283

 

年代: 1993

 

DOI:10.1159/000217826

 

出版商: S. Karger AG

 

关键词: Pituitary neoplasms;Cell cultures;Steroid hormones;Antiestrogens;Steroid receptors

 

数据来源: Karger

 

摘要:

Six human pituitary adenoma cultures, characterized for estrogen and progesterone (Pg) receptors, were treated with 17β-estradiol (17β-E2), Pg and tamoxifen (TAM) at different concentrations, alone and in combination, for 2, 4 and 8 days. Cell proliferation data showed in most cases a stimulating effect of 17β-E2 and an inhibitory effect of Pg on cell growth, which appeared to be correlated with specific receptor expression, but independent of pituitary cell hormone content. A marked inhibitory effect of TAM on cell proliferation was present in all cases, but, on the contrary, was independent of estrogen receptor expressi

 

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