Simultaneous Derivative Spectrophotometric Quantification of Diethylamine Salicylate and Methyl Nicotinate in Ointments
作者:
EzzatM. Abdel-moety,
期刊:
Spectroscopy Letters
(Taylor Available online 1990)
卷期:
Volume 23,
issue 5
页码: 669-677
ISSN:0038-7010
年代: 1990
DOI:10.1080/00387019008054448
出版商: Taylor & Francis Group
关键词: Diethylamine salicylate;methyl nicotinate;ointments;spectrophotometry (derivative)
数据来源: Taylor
摘要:
A direct derivative, D1 i.e. dA/dλ, spectrophotometric procedure for simultaneous determination of diethylamine salicylate and methyl nicotinate in their binary mixtures and in ointments has been investigated. Good percent mean recoveries, 99.68 ± 0.58 & 99.71 ± 0.27 and 100.85 ± 0.21, could be obtained for diethylamine salicylate at 303 nm & 236 nm and methyl nicotinate at 224 nm, in order, added to ointment. The band overlapping in the first order due to the coexisting parabens, main additive, and the water-washable ointment base occurs sufficient away from those wavelengths chosen for the direct D1-measurement of both drug substances.
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