Periconceptional zinc deficiency affects uterine3H‐estradiol binding in mice
作者:
Jeffrey M. Peters,
Lynn M. Wiley,
Sheri Zidenberg‐Cherr,
Carl L. Keen,
期刊:
Teratogenesis, Carcinogenesis, and Mutagenesis
(WILEY Available online 1995)
卷期:
Volume 15,
issue 1
页码: 23-31
ISSN:0270-3211
年代: 1995
DOI:10.1002/tcm.1770150104
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: peri‐implantation development;uterine estrogen binding;zinc;development;reproduction;pregnancy
数据来源: WILEY
摘要:
AbstractTo better define the mechanisms by which zinc (Zn) deficiency influences periconceptional development, we examined the effects of this developmental insult on uterine estrogen metabolism. CD‐1 mice were assigned to 1 of 3 groups (Low Zn, LZ; Control, C; or Replete, R) and fed either a low Zn (⩽0.3 μg Zn/g) or control diet (47 μg Zn/g) 5 days prior to gestation day (GD) 0 and continuing up to GD 4 during early pregnancy. Mice in the R group were fed the low Zn diet until GD 1 after which they were fed the control diet. Uterine3H‐estradiol binding in vivo was measured on GD 2, GD 3, and GD 4. Binding was similar among groups on GD 2 and GD 3, but was lower on GD 4 in LZ mice than in C and R mice (61% of control value). On GD 4, uterine3H‐estradiol binding in vitro was measured and was lower in LZ mice than in C and R mice (63‐‐74% of control values); the reduction in binding was due to lower receptor number. Thus, Zn deficiency can result in a reduction in uterine estradiol receptors and estradiol binding. © 1995 W
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