Parkinsonism Associated With Calcium Channel BlockersA Prospective Follow‐up Study
作者:
Pedro García-Ruiz,
Justo de Yébenes,
Félix Jiménez-Jiménez,
Antonio Vázquez,
Daniel Urra,
Blas Morales,
期刊:
Clinical Neuropharmacology
(OVID Available online 1992)
卷期:
Volume 15,
issue 1
页码: 19-26
ISSN:0362-5664
年代: 1992
出版商: OVID
关键词: Calcium channel blockers;Drug-induced parkinsonism;Long-term prognosis;Reversibility;Aging
数据来源: OVID
摘要:
Parkinsonism is a well-known side effect of some calcium channel blockers (CCB). Its long-term evolution, however, is unknown. To clarify this issue, we performed a prospective follow-up study involving 32 patients diagnosed with CCB-induced parkinsonism. After the baseline examination, the CCB were discontinued and serial evaluations were carried out according to the same protocol. Despite a global improvement, cognitive and mood disturbances subsided slowly, and tremor persisted in most patients. After 18 months of CCB withdrawal, 44% of patients had depression, 88% had tremor, and 33% still had criteria for diagnosis of parkinsonism. During the survey, only three patients were found to be fully recovered. The improvement of some clinical symptoms was related to age: Patients younger than 73 years recovered better than older patients did. Our data indicate that CCB-induced parkinsonism is not the benign condition previously thought, and suggest an age-related prognosis of this entity.
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