L-Tyrosine andL-Tryptophan Transport in Red Blood Cells in Normal Subjects
作者:
J. Widmer,
J.-M. Gaillard,
R. Tissot,
期刊:
Neuropsychobiology
(Karger Available online 1986)
卷期:
Volume 15,
issue 1
页码: 7-12
ISSN:0302-282X
年代: 1986
DOI:10.1159/000118233
出版商: S. Karger AG
关键词: L-Tyrosine;L-Tryptophan;Erythrocytes;Membrane transport
数据来源: Karger
摘要:
Blood cells may be used as a model in the central transport mechanisms of amino acids, precursors of amines, implicated in some hypotheses of psychiatric diseases. In a previous paper, we showed a deficit of tyrosine transport by red cells incubated in the plasma of depressed patients. In the present study, we have investigated the interaction of these peripheral transport mechanisms for tyrosine and tryptophan with other amino acid transports, such as the L and ASC systems, and the role of sodium ions in the extracellular medium. We also describe the inhibition induced by incubation at a low temperature, and a probable role of the membrane viscosity. The interest of incubating the cells in their own plasma, in order to have physiological conditions, is also discussed.
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