Simultaneous Determination of Estrogen and Progesterone Receptors Using Human Uterus as a Standard
作者:
N.Y. Zachariah,
J. Osborne,
Z.H. Chakmakjian,
期刊:
Analytical Letters
(Taylor Available online 1988)
卷期:
Volume 21,
issue 3
页码: 367-380
ISSN:0003-2719
年代: 1988
DOI:10.1080/00032718808066331
出版商: Taylor & Francis Group
关键词: simultaneous determination;hormonal receptors;human uterus extract
数据来源: Taylor
摘要:
Numerous reports have shown a high degree of correlation between the presence of estrogen and progesterone receptors in cancerous breast tumors and response to endocrine therapy. There are several methods in use for measurement of these receptors, but all are time consuming and require large amounts of tumor tissue. Our laboratory needed a faster and simpler method to determine receptor concentration. We describe here an assay which utilizes human uterus extract with known receptor concentration as a standard to determine receptor concentration of tumor tissues. This method is simple, fast and will allow determination of estrogen and progesterone receptor in up to ten patient samples at one time.
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