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Dominant Spinocerebellar Ataxia: Genetic Counseling

 

作者: JacksonJ. F.,   CurrierR. D.,   MortonN. E.,  

 

期刊: Journal of Neurogenetics  （Taylor Available online 1983）
卷期: Volume 1, issue 1  

页码: 87-90

 

ISSN:0167-7063

 

年代: 1983

 

DOI:10.3109/01677068309107074

 

出版商: Taylor&Francis

 

关键词: dominant spinocerebellar ataxia;olivopontocerebellar atrophies (OPCA);genetic counseling;HLA linkage

 

数据来源: Taylor

 

摘要:

Dominantly inherited spinocerebellar ataxia (OPCA 1) poses a particular problem for genetic counseling due to late age of onset. Liability for disease using observed age of onset can be combined with HLA linkage data to provide revised estimates of risk for affection. Where data is informative, certain combinations may yield estimates which improve so rapidly with age that postponement of childbearing may become a strong consideration as an option.

 

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