Case ReportRetinitis Pigmentosa Following Cytotoxic Chemotherapy in Usher's Syndrome
作者:
PAULETTE BLANCHET,
MARK WELLEMEYER,
GARY BURTON,
期刊:
The American Journal of the Medical Sciences
(OVID Available online 1992)
卷期:
Volume 303,
issue 5
页码: 319-320
ISSN:0002-9629
年代: 1992
出版商: OVID
关键词: Usher's syndrome;Retinitis pigmentosa;Chemotherapy toxicity
数据来源: OVID
摘要:
Ocular toxicity is an uncommon complication of cytotoxic chemotherapy. Retinitis pigmentosa complicating cancer chemotherapy has not been reported. A patient with probable Usher's syndrome (congenital sensorineural deafness) had apparent acceleration of retinitis pigmentosa with blindness following cytotoxic chemotherapy for non-Hodgkin's lymphoma. Retinitis pigmentosa, a feature of Usher's syndrome, usually develops as a slowly progressive process. The rapid acceleration of retinopathy following tumor therapy suggests a possible relationship to the cytotoxic chemotherapy. Lymphocytes and fibroblasts from patients with Usher's syndrome are hypersensitive to the x-ray type of DNA-damaging agents. The DNA-damaging effects of chemotherapy may have accelerated the progression of retinitis pigmentosa in this patient.
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