Fatty Acid Metabolism and the Vascular Endothelial Cell
作者:
Michael R. Buchanan,
Gayle L. Crozier,
Thomas A. Haas,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1988)
卷期:
Volume 18,
issue 4-6
页码: 360-375
ISSN:1424-8832
年代: 1988
DOI:10.1159/000215818
出版商: S. Karger AG
关键词: Endothelial cells;13-HODE;prostacyclin;Platelet/leukocyte/tumor cell/ vessel wall interactions
数据来源: Karger
摘要:
Fatty acid metabolism by vascular endothelial cells occurs both under basal conditions and following endothelial cell stimulation or injury. Under basal conditions, endothelial cells are metabolically very active and rapidly turn over triglycerides and synthesize 13-hydroxyoctadecadienoic acid from linoleic acid via the cytosolic enzyme, hω6-lipoxygenase. When endothelial cells are stimulated (or injured), these pathways are turned off, and, instead, arachidonic acid is liberated from the membrane phospholipids and metabolized into prostacyclin via the cyclooxygenase enzyme. The biological relevance of these two fatty acid metabolites is discussed in respect to the regulation of cell/cell interactions during both ‘homeostasis’ and ‘i
点击下载:
PDF
(3101KB)
返 回