Effect of Pyridoxine on the Growth of Morris Hepatoma No. 7288Ctc and Enzyme Activity
作者:
G.P. Tryfiates,
期刊:
Oncology
(Karger Available online 1976)
卷期:
Volume 33,
issue 5-6
页码: 209-211
ISSN:0030-2414
年代: 1976
DOI:10.1159/000225146
出版商: S. Karger AG
关键词: Pyridoxine;Hepatoma;Growth;Depletion;Transaminase
数据来源: Karger
摘要:
The effect(s) of lack of dietary pyridoxine (PX) on the growth of Morris hepatoma no. 7288Ctc was studied. Buffalo strain female rats were fed a diet lacking PX. Pair-fed controls were fed the same diet with PX added. Animals were inoculated with no. 7288Ctc hepatoma cells at 21 days and were sacrificed 16 days later. Host livers and tumors were removed, weights recorded and the activity of tyrosine aminotransferase (TAT; L-tyrosine: 2-oxoglutarate aminotransferase, EC 2.6.1.5) was determined in both host liver and hepatoma. The average weight of 30 hepatomas grown in pair-fed control rats was 11.61 ± 1.5 g while the average weight of the same number of hepatomas grown in animals fed the PX free diet was 4.73 ± 0.7 g (P < 0.001). Further TAT specific activity levels were 39% and 32% higher in host livers and tumors from deficient animals, respectively. The results show that availability of dietary pyridoxine stimulates the growth of this hepatoma and, in addition, exercises a type of control over the expression of TAT activit
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