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Novel Therapeutics for Chemotherapy-Resistant Acute Myeloid Leukaemia

 

作者: Arthur E. Frankel,   Michael W. Schuster,   Joseph G. Jurcic,  

 

期刊: BioDrugs  (ADIS Available online 2001)
卷期: Volume 15, issue 1  

页码: 55-71

 

ISSN:1173-8804

 

年代: 2001

 

出版商: ADIS

 

关键词: Acute myeloid leukaemia, treatment;Anti CD45 monoclonal antibody BC8 I 131, pharmacodynamics;Anti CD45 monoclonal antibody BC8 I 131, therapeutic use;Bryostatin 1, pharmacodynamics;Bryostatin 1, therapeutic use;DT IL 3, pharmacodynamics;G 3139, pharmacody

 

数据来源: ADIS

 

摘要:

Patients with chemotherapy-resistant acute myeloid leukaemia are rarely cured by non-allogeneic transplant therapies. Multiple new investigational agents have become available for treatment of these patients and there are few tools to permit rational drug and clinical trial selection. In this review, we describe the chemical and biological properties of some of these agents and some of their initial clinical activity to date. The selected agents react with either cell surface molecules or signal pathway intermediates and include antibody and antibody conjugates to CD33 and CD45, a fusion protein directed to the granulocyte-macrophage colony-stimulating factor receptor, an anti-sense oligonucleotide to Bcl2, a farnesyl transferase inhibitor, and a protein kinase C agonist/inhibitor. The challenge for the next decade will be how to select patients for particular molecularly targeted therapeutics and how to combine these agents.

 

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