Mathematical Modelling of the Primary and Secondary Drying Stages of Bulk Solution Freeze-Drying in Trays: Parameter Estimation and Model Discrimination by Comparison of Theoretical Results With Experimental Data
作者:
H. Sadikoglu,
A. I. Liapis,
期刊:
Drying Technology
(Taylor Available online 1997)
卷期:
Volume 15,
issue 3-4
页码: 791-810
ISSN:0737-3937
年代: 1997
DOI:10.1080/07373939708917262
出版商: Taylor & Francis Group
关键词: Freeze-drying of pharmaceuticals;lyophilization of pharmaceuticals
数据来源: Taylor
摘要:
A mathematical model was constructed and solved in order to describe quantitatively the dynamic behavior of the primary and secondary drying stages of the freeze-drying of pharmaceuticals in trays. The theoretical results were compared with the experimental data of the freeze-drying of skim milk, and the agreement between the experimental data and the theoretical results is good. Detailed model calculations have indicated that the contribution of the removal of hound (unfrozen) water to the total mass flux of the water removed during primary drying, is not significant. For this reason, it was found that one could not
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