Comparative Effects of Chemotherapeutic Drugs on Human and Murine Hematopoietic Progenitors in vitro
作者:
Akira Horikoshi,
Martin J. Murphy Jr.,
期刊:
Chemotherapy
(Karger Available online 1982)
卷期:
Volume 28,
issue 6
页码: 480-501
ISSN:0009-3157
年代: 1982
DOI:10.1159/000238139
出版商: S. Karger AG
关键词: CFU-gm;CFU-e;BFU-e;K-562 human leukemia cell line;Daunorubicin;Cytosine arabinoside;Vincristine;Methotrexate;Bis-chlorethyl-nitrosourea;Chlorozotocin
数据来源: Karger
摘要:
Using semi-solid clonal assay systems, the cytocidal effects of chemotherapeutic drugs on hematopoietic progenitors (CFU-gm, BFU-e, CFU-e) were compared with their effects on K-562 human leukemia cells. The chemotherapeutic drugs used for these experiments were daunorubicin, cytosine arabinoside, vincristine, methotrexate, bis-chlorethyl-nitrosourea and chlorozotocin. After the cells were exposed for either 1 or 24 h to several concentrations of each drug, clear differences in suppressive effects were seen. The experimental applications of this technology and the clinical implication of these results are discussed.
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