Mammalian andEscherichia colisignal recognition particles
作者:
Joen Luirink,
Bernhard Dobberstein,
期刊:
Molecular Microbiology
(WILEY Available online 1994)
卷期:
Volume 11,
issue 1
页码: 9-13
ISSN:0950-382X
年代: 1994
DOI:10.1111/j.1365-2958.1994.tb00284.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
SummaryRecent evidence from both biochemical and genetic studies indicates that protein targeting to the pro‐karyotic cytoplasmic membrane and the eukaryotic endoplasmic reticulum membrane may have more in common than previously thought. A ribonucleo‐protein particle was identified inEscherichia colithat consists of at least one protein (P48 or Ffh) and one RNA molecule (4.5S RNA), both of which exhibit strong sequence similarity with constituents of the mammalian signal recognition particle (SRP). Like the mammalian SRP, theE. coliSRP binds specifically to the signal sequence of presecretory proteins. Depletion of either P48 or 4.5S RNA affects translation and results in the accumulation of precursors of several secreted proteins. This review discusses these recent studies and speculates on the position of the SRP in the complex network of protein interactions involved in translation and membrane targeting inE. c
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