Melatonin Inhibition of Pineal Enzymes inCoturnixQuail
作者:
N. Wright,
J.P. Preslock,
期刊:
Neuroendocrinology
(Karger Available online 1975)
卷期:
Volume 19,
issue 2
页码: 177-184
ISSN:0028-3835
年代: 1975
DOI:10.1159/000122438
出版商: S. Karger AG
关键词: Pineal;Melatonin;Hydroxyindole-O-methyl transferase;N-acetyl transferase;Coturnixquail;Regulatory mechanisms
数据来源: Karger
摘要:
The activities of the melatonin-forming enzymes hydroxyindole-O-methyl transferase (HIOMT) and N-acetyl transferase (NAT) were determined in pineals of mature female Coturnix quail receiving implants of melatonin (10 µg, 1 µg, 0.1 µg) weekly for 4 weeks. Both HIOMT and NAT were significantly decreased by implants of 10 and 1 µg melatonin compared to vehicle and intact controls. Oviductal weights tended to be higher with increasing quantities of melatonin. These results suggest that melatonin exerts a feedback inhibition upon its synthesizing enzymes which may be of particular importance during the rapid sexual maturation of this spec
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