Systemic Nocardiosis in a Splenectomized Patient with Systemic Lupus ErythematosusSuccessful Treatment Using Linezolid
作者:
Rupak Moitra,
Cressida Auckland,
Michael Cawley,
Graeme Jones,
Cyrus Cooper,
期刊:
JCR: Journal of Clinical Rheumatology
(OVID Available online 2003)
卷期:
Volume 9,
issue 1
页码: 47-50
ISSN:1076-1608
年代: 2003
出版商: OVID
关键词: Nocardiosis;Systemic lupus erythematosus;Linezolid
数据来源: OVID
摘要:
A splenectomized patient with systemic lupus erythematosus, who had previously been treated with high doses of corticosteroids, presented with headaches and symptoms of a respiratory tract infection. A magnetic resonance imaging scan of the brain revealed a ring-enhancing lesion, andNocardia asteroideswas isolated from a stereotactic biopsy specimen. After adverse reactions to a number of antibiotics, infection control was finally achieved by the new oxazolidinone drug, linezolid. Nocardiosis should be considered as a differential diagnosis in all immunocompromised patients who develop an obscure infection; delay in diagnosis and subsequent initiation of appropriate treatment often results in a fatal outcome. Linezolid is a new option for the treatment of nocardiosis and is effective when given orally.
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