Effect of Ethanol on Human Umbilical Artery and Vein in vitro
作者:
Hsing-Yi Yang,
Andrew Yau-Chik Shum,
Heung-Tat Ng,
Chieh-Fu Chen,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1986)
卷期:
Volume 21,
issue 3
页码: 131-135
ISSN:0378-7346
年代: 1986
DOI:10.1159/000298942
出版商: S. Karger AG
关键词: Ethanol;Human umbilical artery;Human umbilical vein
数据来源: Karger
摘要:
In vitro effects of ethanol on human umbilical artery and vein were studied. Ethanol (0.5–2.0%) elicited a dose-dependent contractile response both in the umbilical arterial and venous strips in Krebs’ and Ca2+-free Krebs’ solution. In umbilical artery, but not in vein, ethanol shifted the Ca2+-induced dose-response curves to the right in a parallel manner along with a significant reduction in K+-depolarized maximal tension. These result demonstrate that ethanol can elicit a potent contractile response both in human umbilical arteries and veins and could aid in explaining why ethanol can induce the fetal alcohol syndrome.
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