首页   按字顺浏览 期刊浏览 卷期浏览 Rapid Method for Determination of Disopyramide and Its Mono-N-Dealkylated Metabolite in...
Rapid Method for Determination of Disopyramide and Its Mono-N-Dealkylated Metabolite in Serum by High-Performance Liquid Chromatography Using Sep-Pak Silica Extraction

 

作者: Hiroaki Kubo,   Toshio Kinoshita,   Yoshie Kobayashi,   Ken Tokunaga,  

 

期刊: Analytical Letters  （Taylor Available online 1984）
卷期: Volume 17, issue 1  

页码: 55-68

 

ISSN:0003-2719

 

年代: 1984

 

DOI:10.1080/00032718408065264

 

出版商: Taylor & Francis Group

 

关键词: disopyramide;mono-N-dealkyldisopyramide reversed phase high-performance liquid chromatography;Sep-Pak silica extraction;human serum

 

数据来源: Taylor

 

摘要:

A rapid, simple and reproducible method for sample pretreatment and analysis of disopyramide and its mono-N-dealkylated metabolite in serum is described. Samples for analysis were prepared by using Sep-Pak silica cartridge treated with 1 N sodium hydroxide followed by elution in 8 ml ethyl acetate. The eluate was back-extracted with acidic solution and an aliquot of the solution was injected directly onto the column.

 

点击下载:  PDF (361KB)



返 回