Tissue-Specific Regulation of Pyroglutamate Aminopeptidase II Activity by Thyroid Hormones
作者:
Georgina Ponce,
Jean-Louis Charli,
Jorge A. Pasten,
Carmen Aceves,
Patricia Joseph-Bravo,
期刊:
Neuroendocrinology
(Karger Available online 1988)
卷期:
Volume 48,
issue 2
页码: 211-213
ISSN:0028-3835
年代: 1988
DOI:10.1159/000125011
出版商: S. Karger AG
关键词: TRH catabolism;Pyroglutamate aminopeptidase II;Thyroid status;Thyroliberinase;Adenohypophysis
数据来源: Karger
摘要:
Among the enzymes capable of degrading thyrotropin-releasing hormone (TRH) in vitro, two pyroglutamate aminopeptidases (PGA) are specific for TRH: thyroliberinase, a seric enzyme and PGAII, a membrane-bound peptidase. The effect of thyroid hormone status on the activity of these enzymes was evaluated in serum and various tissues. Only in adenohypophysis, triiodothyronine treatment increased PGAII to 376% of control; hypothyroidism produced the reverse effect (decrease to 23% of control). As previously reported, similar changes were observed for thyroliberinase. TRH degradation at the adenohypophysis level may participate in the negative feedback control of thyroid hormones.
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