Screening of Fetal Stem Cells for Infection and Cytogenetic Abnormalities
作者:
Sverker Ek,
Magnus Westgren,
Helmut Pschera,
Åke Seiger,
Erik Sundström,
T.H. Bui,
Olle Ringdén,
期刊:
Fetal Diagnosis and Therapy
(Karger Available online 1994)
卷期:
Volume 9,
issue 6
页码: 357-361
ISSN:1015-3837
年代: 1994
DOI:10.1159/000264065
出版商: S. Karger AG
关键词: Stem cell transplantation;Tissue bank;Infection screening;Therapeutic abortion
数据来源: Karger
摘要:
Fetal stem cell transplantation may rely on material from therapeutic abortions. It is essential that the stem cell transplant does not transmit any microorganism that may affect the fetus and that genetically abnormal cells are avoided. To evaluate such contamination, human fetal stem cells collected February 1992 – December 1993 were analyzed for bacterial and fungal growth, and the placentas were karyotyped. Four samples of 70 were positive for different pathogens. Serological screening of 43 women during this period resulted in five seroconver-sions and revealed one carrier of anti-HCV. Karyotyping revealed two abnormal findings out of 72 samples. Thus, the concept of using material from therapeutic abortions is saf
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