Oral Glucose Tolerance Test After High-Dose i.v. Biotin Administration in Normoglucemic Hemodialysis Patients
作者:
KoutsikosDimitris,
FourtounasConstantinos,
KapetanakiAntigoni,
AgroyannisBasil,
TzanatosHelen,
RammosGeorge,
KopeliasLoannis,
BosiolisBasil,
BovoletiOlympia,
DaremaMaria,
SallumGeorge,
期刊:
Renal Failure
(Taylor Available online 1996)
卷期:
Volume 18,
issue 1
页码: 131-137
ISSN:0886-022X
年代: 1996
DOI:10.3109/08860229609052783
出版商: Taylor&Francis
关键词: Biotin;Glucose metabolism;Hemodialysis
数据来源: Taylor
摘要:
Abnormal glucose metabolism in uremia may result from a complex interplay between decreased insulin secretion and insulin resistance. Recent studies report beneficial effect of biotin administration in glucose metabolism in diabetic animals and in a small number of patients with diabetes mellitus. The aim of the present study was to evaluate the response of oral glucose tolerance test (OGTT) to the i.v. administration of large doses of biotin in hemodialysis patients. Eleven hemodialysis patients aged 56.90±11.20 (32–76) years on regular hemodialysis thrice a week for 2.72±1.79 (1–7) years were studied. Fasting venous plasma glucose, glucosylated hemoglobin (%GH), and plasma glucose concentration 2 h after the administration of a 75-g glucose load were measured before, and 2 weeks and 2 months after administration of 50 mg of biotin i.v. postdialysis, and after a 2-month washout period. During the study, dialysis schedule and patients' medication, diet, and dry weight were kept unchanged. OGTT was abnormal in 4 patients before biotin administration and became normal in 3 patients (75%). Our results offer support to the findings of other studies about the beneficial effect of biotin in experimental or clinical diabetes mellitus, and argue for the involvement of biotin in glucose metabolism.
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