Open Study of Intravenous Recombinant Hirudin (CGP 39393) on Platelet Function and Coagulation in Healthy Volunteers
作者:
Bernard Hoet,
Istvan Tornai,
Jozef Arnout,
Philippe Close,
Jos Vermylen,
Marc Verstraete,
期刊:
Drug Investigation
(ADIS Available online 1994)
卷期:
Volume 7,
issue 3
页码: 127-133
ISSN:0114-2402
年代: 1994
出版商: ADIS
数据来源: ADIS
摘要:
Ten healthy male volunteers not previously exposed to hirudin participated in an open trial to evaluate the effects on platelet function and coagulation of recombinant hirudin (rec-hirudin) CGP 39393 1 mg/kg administered intravenously as a bolus injection.The activated partial thromboplastin time (APTT) at 90 minutes, 8 hours and 12 hours after administration, was prolonged by 2.3, 1.4 and 1.3 times the baseline value, respectively. The APTT was closely correlated with the plasma concentration of rec-hirudin CGP 39393, and was doubled at plasma concentrations of about 60 nmol/L (400 ng/ml).Ex vivoplatelet aggregation stimulated by a variety of inducers (except thrombin) was not inhibited. Serum thromboxane B2and &bgr;-thromboglobulin levels decreased 20 minutes after injection, the reduction being significant only for serum thromboxane B2.
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