Spectrophotometric Determination of Some Tranquillizers and Antidepressants Using 2,3-Dichloro 5,6-Dicyano-p-Benzoquinone
作者:
M. Abdel-salam,
A.S. Issa,
M. Mahrous,
M.E. Abdel-hamid,
期刊:
Analytical Letters
(Taylor Available online 1985)
卷期:
Volume 18,
issue 11
页码: 1391-1403
ISSN:0003-2719
年代: 1985
DOI:10.1080/00032718508066219
出版商: Taylor & Francis Group
关键词: chlorpromazine;imipramine;amitriptyline;chlorprothexine analysis;spectrophotometry;electron spin resonance
数据来源: Taylor
摘要:
A simple and sensitive spectrophotometric method is described for the assay of some tranquillizers and antidepressants, namely, chlorpromazine, imipramine, amitriptyline and chlorprothexine. The method was based on the interaction of these drugs as n-electron donors with 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) as λ -acceptor to give a highly coloured radical anion which exhibits maximum absorption at 460 nm. The radical anion was proved by electron spin resonance measurements. The proposed method has been successfully applied for the determination of the examined drugs in tablets. The assay results were in accord with the pharmacopoeial results.
点击下载:
PDF (359KB)
返 回