Vickers hardness in spinel increases by 23% after neutron irradiation to a fluence of 8.3 × 1022n/m2at 100°C. Annealing at high temperatures above 100°C gradually decreases the hardness. Above 500°C, the hardness is reduced to almost the same value as that of unirradiated material. The hardness of spinel, irradiated at 470°C to a fluence of 2.4 × 1024n/m2, is unchanged both after irradiation and after annealing up to 1000°C. The length change during annealing was also measured and is similar to the hardness change. Frank dislocation loops with a density of 3 × 1014/cm3are induced by neutron irradiation at 470°C but they apparently do not affect the hardening in spinel. Thus, point defects are concluded to act as obstacles against dislocation movement. The yield stress measured at 1400°C is also unchanged after irradiation. It is believed that not only the point defects but also the loops are annihilated by annealing