Behavioral and neurochemical studies on the anticonflict actions of buspirone
作者:
B. A. Weissman,
J. E. Barrett,
L. S. Brady,
J. M. Witkin,
W. B. Mendelson,
S. M. Paul,
P. Skolnick,
期刊:
Drug Development Research
(WILEY Available online 1984)
卷期:
Volume 4,
issue 1
页码: 83-93
ISSN:0272-4391
年代: 1984
DOI:10.1002/ddr.430040110
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: buspirone;CGS 8216;Ro 15‐1788;benzodiazepine receptor
数据来源: WILEY
摘要:
AbstractA series of behavioral and neurochemical studies were performed in order to determine if buspirone (or an active metabolite of this compound) could perturb a component of the γ‐aminobutyric (GABA)‐benzodiazepine receptor‐chloride ionophore complex. In confirmation of previous findings, buspirone was shown to have anticonflict actions in both the rat and monkey. However, in these tests, buspirone was not as efficacious as benzodiazepines in producing an anticonflict action. The benzodiazepine receptor antagonists CGS 8216 and Ro 15–1788 did not reverse the anticonflict actions of buspirone. Small but statistically significant increases in the binding of [3H]diazepam to brain were observed in vivo after doses of buspirone which are active in the “thirsty rat conflict” test. However, a similar change was not observed in the ex vivo binding of [3H]flunitrazepam. These observations suggest that a metabolite of buspirone may perturb some component of the GABA‐benzodiazepine receptor‐chloride ionophore complex in an indirect fashion. Further work is necessary to determine whether a causal relationship exists between the changes in [3H]diazepam binding observed in vivo and the anticonflict acti
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