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Stereotactic Heavy‐Charged‐Particle Bragg Peak Radiosurgery for the Treatment of Intracranial Arteriovenous Malformations in Childhood and Adolescence

 

作者: Richard Levy,   Jacob Fabrikant,   Kenneth Frankel,   Mark Phillips,   John Lyman,  

 

期刊: Neurosurgery  (OVID Available online 1989)
卷期: Volume 24, issue 6  

页码: 841-852

 

ISSN:0148-396X

 

年代: 1989

 

出版商: OVID

 

关键词: Arteriovenous malformation;Bragg peak radiosurgery;Heavy‐charged‐particles;Intracranial hemorrhage;Pediatric neurology;Radiosurgery;Stereotactic radiosurgery

 

数据来源: OVID

 

摘要:

&NA;Forty patients aged 6 to 18 years have now been treated for inoperable intracranial arteriovenous malformations (AVMs) using stereotactic heavy‐charged‐particle Bragg peak radiosurgery at the Lawrence Berkeley Laboratory 184‐inch Synchrocyclotron at the University of California, Berkeley. This paper describes the procedures for selection of patients, the treatment protocol, and the neurological and neuroradiological responses to stereotactic radiosurgery in this age group. The volumes of the treated AVMs ranged from 265 mm3to 60,000 mm3. The results are favorable: thus far, 20 of 25 patients have experienced ≥50% obliteration of their AVMs within 1 year after treatment, and 14 of 18 patients have experienced total obliteration of the AVM by 2 years after treatment. Two patients hemorrhaged from radiosurgically treated AVMs within 12 months after treatment, but none thereafter. Complications include vasogenic edema and arterial occlusion; three patients have had neurological worsening as definite or possible sequelae of treatment. The strengths and limitations of the method are discussed. (Neurosurgery24:841‐852, 1989)

 

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