Neue 16α‐Hydroxysteroide aus menschlichem Urin und aus Schweine‐Nebennieren. Isolierung, Konstitution, Synthesen. über Steroide, 156. Mitteilung
作者:
R. Neher,
Ch. Meystre,
A. Wettstein,
期刊:
Helvetica Chimica Acta
(WILEY Available online 1959)
卷期:
Volume 42,
issue 1
页码: 132-152
ISSN:0018-019X
年代: 1959
DOI:10.1002/hlca.19590420111
出版商: WILEY‐VCH Verlag GmbH
数据来源: WILEY
摘要:
AbstractSome new compounds, including 3α, 16α‐dihydroxy‐pregnan‐20‐one (I) and 3α, 16α‐dihydroxy‐allopregnan‐20‐one (III), have been isolated from urine of patients with clinically compensated adrenogenital salt‐losing syndrome. Compound I seems to be responsible for the original salt loss. This effect could be demonstrated under certain conditions in male adrenalectomized rats. Compound III was also isolated from hog adrenals. The synthesis of these steroids and of a few others, stereoisomeric in positions 3, 5 and 16, and of a 5,6‐dehydro analog is described. There is some preliminary evidence for the presence of compound I and III in urines of origin other than patients with
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