Comparative Evaluation of Zinc Sulfadiazine aims Silver Sulfadiazine in Burn Wound Infection
作者:
Charles Fox,
T N Vyasa Rao,
R Azmeth,
S S Gandhi,
Shanta Modak,
期刊:
Journal of Burn Care & Rehabilitation
(OVID Available online 1990)
卷期:
Volume 11,
issue 2
页码: 112-117
ISSN:0273-8481
年代: 1990
出版商: OVID
数据来源: OVID
摘要:
One percent silver sulfadiazine has been commonly used as a topical antimicrobial agent after a burn injury. Incidence of burn wound colonization byStaphylococcus aureusin patients treated with silver sulfadiazine has spurred research for other agents. A topical preparation that contains zinc and sulfadiazine (Zad-G) was evaluated for in vitro antibacterial spectrum and in vivo efficacy. Muscle biopsy specimens of rats treated with Zad-G appear to have fewer colonies ofS. aureusthan groups treated with silver sulfadiazine. Topical therapy with Zad-G for patients with burns was comfortable, reduced wound infection, and was comparable to therapy with silver sulfadiazine. A topical Zad-G preparation that contains zinc sulfadiazine appears to be an effective alternative to silver sulfadiazine in the treatment of burn wounds.
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