The purpose of this study was to describe problems occurring in adolescents with cystic fibrosis that related to home or hospital care, maternal concerns, and the role of the health-care professional in promoting care. Forty-question semistructured interviews of adolescents (N = 20) and their mothers (N = 12) were used. Interrater reliability (90%) was established through analysis of 8 audiotaped interviews and agreement on content analysis of the 32 interviews. Results are discussed according to five categories of concerns identified by adolescents: (a) knowledge deficits, (b) self-care/decision making, (c) home care management, (d) hospital care management, and (e) suggestions for health professionals. Mothers described six categories of concern: (a) fear, (b) effect on self, (c) disruption of family life, (d) health-care management at home, (e) health-care management in the hospital, and (f) suggestions for health professionals.