Opiate-Androgen Interactions in Drug-Induced Yawning and Penile Erections in the Rat
作者:
Hemmie H.G. Berendsen,
Alma J. Gower,
期刊:
Neuroendocrinology
(Karger Available online 1986)
卷期:
Volume 42,
issue 3
页码: 185-190
ISSN:0028-3835
年代: 1986
DOI:10.1159/000124438
出版商: S. Karger AG
关键词: Yawning;Penile erections;Apomorphine;Physostigmine;Opiates;Dihydro-testosterone;Castration
数据来源: Karger
摘要:
The effects of pretreatment with drugs on drug-induced yawning and penile erection in intact and chronically castrated rats were investigated. Naloxone partially blocked yawning in intact rats and in castrated rats pretreated with dihydro-testosterone propionate (DHTP) but not in control castrates. In contrast, naloxone potentiated apomorphine-induced penile erections in intact rats. Morphine, haloperidol and atropine blocked yawning and penile erections. Methyl naloxone, methyl atropine and domperidone at doses which are selectively peripheral-acting had no effect on drug-induced yawning or penile erection indicating that both effects are mediated centrally. Pretreatment with morphine did not change the naloxone effects in intact rats. The results indicate a naloxone-androgen interaction in drug-induced yawning but the results with morphine are not consistent with a role of opiates in this interaction. The penile erection data support a direct opiate-dopamine receptor interaction in this response. The haloperidol and atropine effects support a cholinergic-dopaminergic interaction in both yawning and penile erections.
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