Pharmacokinetics of Mezlocillin in Patients with Kidney Impairment: Special Reference to Hemodialysis and Dosage Adjustments in Relation to Renal Function
作者:
J.M. Brogard,
F. Comte,
M.O. Spach,
J. Lavillaureix,
期刊:
Chemotherapy
(Karger Available online 1982)
卷期:
Volume 28,
issue 5
页码: 318-326
ISSN:0009-3157
年代: 1982
DOI:10.1159/000238098
出版商: S. Karger AG
关键词: Pharmacokinetics;Mezlocillin;Normal subjects;Renal impairment;Hemodialysis;Dosage adjustments
数据来源: Karger
摘要:
The pharmacokinetics of Mezlocillin were determined after the intramuscular injection of a single 1-gram dose in 10 subjects with normal renal function, in 10 patients with stabilized renal impairment and in 5 patients with end-stage renal disease submitted to repeated hemodialysis. In normal subjects, biological half-life, Tb ½„ was equal to 0.9 h; total clearance (Ct) to 449 ml/min/1.73 m2; renal clearance (Cr) to 263 ml/min/1.73 m2.72.2% of the administered dose was excreted in the urine within 12 h. In patients with renal insufficiency and in patients undergoing long-term hemodialysis, the serum concentration decrease was markedly slower. During a 6-hour dialysis session, 62% of the Mezlocillin present in the central compartment at the start of hemodialysis was removed. In the 25 subjects under study, a significant correlation was found between the values of Ke and those of creatinine clearance, Ccr (Ke=0.1973+ 0.0046 Ccr). This relation was used to calculate the loading doses, the maintenance doses and the dosage intervals adjusted to the degree of renal impairment, allowing assessment of useful dosage recommendatio
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